Unni, Emmanual ; Kssari, K. V. ; Rao, M. R. S. (1984) Effect of vitamin A deprivation on the mitogenic factor activity in the rat testes Biochemical and Biophysical Research Communications, 125 (2). pp. 454-462. ISSN 0006-291X
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0006-291X(84)90562-X
Abstract
The seminiferous tubules of rat testes contain a protease and heat sensitive factor capable of stimulating (3H)-thymidine incorporation into quiescent cultures of NIH 3T3 mouse fibroblast cells. This mitogenic factor activity was only 4% in the testes of vitamin A deficient-retinoic acid maintained rats as compared to that of normal rats. Supplementation of retinyl acetate to these vitamin A deficient rats for 4 days resulted in a 56% recovery in the mitogenic factor activity while by day 16, the recovery was 80 percent. Incorporation of (3H)-thymidine into DNA of the seminiferous tubules of vitamin A deficient rats was only 46% of that of normal rats which was restored to normal levels by retinyl acetate supplementation for 24 days.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 42555 |
| Deposited On: | 04 Jun 2011 11:21 |
| Last Modified: | 04 Jun 2011 11:21 |
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