Kolodner, R. D. ; Hall, N. R. ; Lipford, J. ; Kane, M. F. ; Rao, M. R. S. ; Morrison, P. ; Wirth, L. ; Finan, P. J. ; Burn, J. ; Chapman, P. ; Earabino, C. ; Merchant, E. ; Bishop, D. T. ; Garber, J. ; Bronner, C. E. ; Baker, S. M. ; Warren, G. ; Smith, L. G. ; Lindblom, A. ; Tannergard, P. ; Bollag, R. J. ; Godwin, A. R. ; Ward, D. C. ; Nordenskjold, M. ; Liskay, R. M. ; Copeland, N. ; Jenkins, N. ; Lescoe, M. K. ; Ewel, A. ; Lee, S. ; Griffith, J. ; Fishel, R. (1994) Human mismatch repair genes and their association with hereditary non-polyposis colon cancer Cold Spring Harbor Symposia on Quantitative Biology, 59 . pp. 331-338. ISSN 0091-7451
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Official URL: http://symposium.cshlp.org/content/59/331.short
Related URL: http://dx.doi.org/10.1101/SQB.1994.059.01.037
Abstract
Hereditary non-polyposis colon cancer (HNPCC) may affect up to 1 in 200 people in industrialized nations (Bishop and Thomas 1990; Lynch et al. 1991, 1993; Peltomaki et al. 1993b). Four genes have been identified in which inherited mutations appear to cause HNPCC. hMSH2 on chromosome 2p21-22 appears to account for up to 60% of HNPCC (Fishel et al. 1993; Leach et al. 1993; Sandkuijl and Bishop 1993; Nystrom-Lahti et al. 1994), hMLH1 on chromosome 3p21 appears to account for up to 30% of HNPCC (Bronner et al. 1994; Nystrom-Lahti et al. 1994; Papadopoulos et al. 1994), and hPMS1 on chromosome 2q31-33 and hPMS2 on chromosome 7p21 may account for 5% of HNPCC (Nicolaides et al. 1994).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Cold Spring Harbor Laboratory Press. |
| ID Code: | 42521 |
| Deposited On: | 04 Jun 2011 10:24 |
| Last Modified: | 04 Jun 2011 10:24 |
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