Cyclic peptides- small and big and their conformational aspects

Ramakrishnan, C. ; Paul, P. K. C. ; Ramnarayan, K. (1985) Cyclic peptides- small and big and their conformational aspects Journal of Biosciences, 8 (1&2). pp. 239-251. ISSN 0250-5991

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Cyclic peptides form an interesting class of compounds for study by conformational analysis, by virtue of their unique conformational features and biological properties. The small cyclic peptides having 3-6 peptide units in their ring, show a variety of conformational characteristics such as occurrence ofcis peptide units, flexibility of peptide dimension and variety in hydrogen bonding. The different possible conformations of cyclic tri- and hexa-peptides are given and certain specific conformational features are discussed for cyclic tetra and pentapeptides. For higher cyclic peptides, the hydrogen bonding requirement for stability of the backbone of the ring, is seen to be kept to a minimum. These various features and their significance are examined and discussed in the light of energy minimization studies and analysis of available experimental data.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Cyclic Peptides; Hydrogen Bonding; Symmetry; Cyclic Hexapeptides; Energy Minimization; Peptide Conformation
ID Code:41033
Deposited On:26 May 2011 07:05
Last Modified:17 May 2016 22:53

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