Hillyard, David R. ; Monje, Virginia D. ; Mintz, Isabelle M. ; Bean, Bruce P. ; Nadasdi, Laszlo ; Ramachandran, J. ; Miljanich, G. ; Azimi-Zoonooz, Aryan ; Michael McIntosh, J. ; Cruz, Lourdes J. ; Imperial, Julita S. ; Olivera, Baldomero M. (1992) A new conus peptide ligand for mammalian presynaptic Ca2+ channels Neuron, 9 (1). pp. 69-77. ISSN 0896-6273
Full text not available from this repository.
Official URL: http://www.cell.com/neuron/retrieve/pii/0896627392...
Related URL: http://dx.doi.org/10.1016/0896-6273(92)90221-X
Abstract
Voltage-sensitive Ca2+ channels that control neurotransmitter release are blocked by w-conotoxin (ω-CgTx) GVIA from the marine snail Conus geographus, the most widely used inhibitor of neurotransmitter release. However, many mammalian synapses are ω-CgTx-GVIA insensitive. We describe a new Conus peptide, w-CgTxMVIIC, that is an effective inhibitor of ω-CgTx-GVIA-resistant synaptic transmission. Ca2+ channel targets that are inhibited by ω-CgTx-MVIIC but not by ω-CgTx-GVIA include those mediating depolarization-induced 45Ca2+ uptake in rat synaptosome preparations, "P" currents in cerebellar Purkinje cells, and a subset of ω-CgTx-GVIA-resistant currents in CA1 hippocampal pyramidal cells. The characterization of ω-CgTx-MVIIC by a combination of molecular genetics and chemical synthesis defines a general approach for obtaining ligands with novel receptor subtype specificity from Conus.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 40959 |
| Deposited On: | 25 May 2011 10:28 |
| Last Modified: | 25 May 2011 10:28 |
Repository Staff Only: item control page
