Antitumour immunity - 1. Differential response of neuraminidase-treated and X-irradiated tumour vaccine

Ray, P. K. ; Thakur, V. S. ; Sundaram, K. (1975) Antitumour immunity - 1. Differential response of neuraminidase-treated and X-irradiated tumour vaccine European Journal of Cancer (1965), 11 (1). pp. 1-8. ISSN 0014-2964

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/001429...

Related URL: http://dx.doi.org/10.1016/0014-2964(75)90030-4

Abstract

A dimethyl-benz-dithionapthene-induced fibrosarcoma shows reduced transplantability in syngeneic Swiss mice when treated with Vibrio cholerae neuraminidase (VCN). Reduced transplantability of fibrosarcoma has also been observed if they are X-irradiated. Inoculation of VCN treated cells leads to the development of strong antitumour immunity, whereas comparable results are not obtained with X-irradiated cells. However, inoculation of cells treated with VCN followed by X-irradiation can also establish lasting antitumour immunity. It is suggested that 'tumour vaccine' produced in this way may be very effective for the immunotherapy of tumour.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:40759
Deposited On:25 May 2011 05:39
Last Modified:25 May 2011 05:39

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