Evaluation of freshly irradiated wheat for dominant lethal mutations in wistar rats

Chauhan, Pawan S. ; Aravindakshan, M. ; Kumar, N. S. ; Subba Rao, V. ; Aiyar, A. S. ; Sundaram, K. (1977) Evaluation of freshly irradiated wheat for dominant lethal mutations in wistar rats Toxicology, 7 (1). pp. 85-97. ISSN 0300-483X

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/030048...

Related URL: http://dx.doi.org/10.1016/0300-483X(77)90040-3


Three independent, serially performed experiments involving acute and chronic feeding of freshly irradiated wheat (75 krad, gamma-irradiation) were carried out in Wistar rats. In the forst experiment groups of 10 males were given wheat for 1 week; irradiated wheat was consumed by the animals within 24 h of irradiation. In the other two experiments feeding of males was continued for 6 (10 males per group) and 12 (13 males per group) weeks, respectively, and the irradiated wheat was fed within 7 days of irradiation. At the end of each treatment period each male was paired with 3 females for 7 days and sequentially at weekly intervals for 5 or 8 weeks. Females were killed and examined for live and dead implantations and corpora lutea. There were no differences between groups with regard to fertility nor was there any inter-group difference as regards pre- and post-implantation losses whether the rats were fed irradiated or non-irradiated wheat. This suggested that even feeding of freshly irradiated wheat does not induce any dominant lethal mutations in rats.

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