Pituitary corticotropin-inhibiting peptide: properties and use in study of corticotropin action

Lee, C. Y. ; Mcpherson, Margaret ; Licko, Vojtech ; Ramachandran, J. (1980) Pituitary corticotropin-inhibiting peptide: properties and use in study of corticotropin action Archives of Biochemistry and Biophysics, 201 (2). pp. 411-419. ISSN 0003-9861

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000398...

Related URL: http://dx.doi.org/10.1016/0003-9861(80)90529-9

Abstract

The biological properties of the naturally occurring pituitary peptide αh7−38-adrenocorticotropin (ACTH) have been investigated. αh7−38-ACTH is devoid of steroidogenic activity but inhibits competitively ACTH-induced steroidogenesis in vitro as well as in vivo. The long-term actions of ACTH on normal and tumor adrenal cells in culture are also antagonized by αh7−38-ACTH. The apparent Ki for the inhibition of cyclic AMP production by αh7−38-ACTH (301±62 nM) was significantly higher than the apparent Ki for the inhibition of corticosterone synthesis (21.6±6.8 nM). Analysis of the inhibition of ACTH-induced steroidogenesis and cyclic AMP production in normal rat adrenocortical cells indicates that two separate receptors may be involved in mediating these responses.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:40735
Deposited On:25 May 2011 05:25
Last Modified:25 May 2011 05:25

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