Schofield, Peter R. ; Darlison, Mark G. ; Fujita, Norihisa ; Burt, David R. ; Anne Stephenson, F. ; Rodriguez, Henry ; Rhee, Lucy M. ; Ramachandran, J. ; Reale, Vincenzina ; Glencorse, Thora A. ; Seeburg, Peter H. ; Barnard, Eric A. (1987) Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family Nature, 328 . pp. 221-227. ISSN 0028-0836
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Official URL: http://www.nature.com/nature/journal/v328/n6127/ab...
Related URL: http://dx.doi.org/10.1038/328221a0
Abstract
Amino-acid sequences derived from complementary DMAs encoding the α- and β-subunits of the GAB A/ benzo diazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated α-subunit and β-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Nature Publishing Group. |
| ID Code: | 40717 |
| Deposited On: | 25 May 2011 05:26 |
| Last Modified: | 25 May 2011 05:26 |
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