Effect of a gluten-free diet on growth and small-bowel histology in children with celiac disease in India

Yachha, Surender K. ; Srivastava, Anshu ; Mohindra, Samir ; Krishnani, Narendra ; Aggarwal, Rakesh ; Saxena, Anita (2007) Effect of a gluten-free diet on growth and small-bowel histology in children with celiac disease in India Journal of Gastroenterology and Hepatology, 22 (8). pp. 1300-1305. ISSN 0815-9319

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Official URL: http://www3.interscience.wiley.com/journal/1185341...

Related URL: http://dx.doi.org/10.1111/j.1440-1746.2007.04929.x


Background and Aim: Follow-up studies on growth and histological recovery of children with celiac disease (CD) while on a gluten-free diet (GFD) are lacking from Asia. We therefore assessed the effects of this diet. Methods: Forty-two children with CD were enrolled. Weight and height were expressed as weight for height (WfH) and height standard deviation scores (HSDS), respectively. Twenty-five children had repeated duodenal biopsies after 1-2 years and 14 had a third biopsy after 3-7 years of GFD. Compliance was checked by regular interview and IgA antiendomysial antibody estimation (EMA). Results: At diagnosis (n = 25), mean HSDS was -3.3 ± 1.6 with 76% having a HSDS of <-2; 60% were undernourished (WfH mean 81.6 ± 5.7). Over a mean follow up of 3.7 years, HSDS improved to -1.3 ± 1.7 and 84% cases achieved normal nutrition. Mean height velocity was 13.9 cm during first year and 5.6 cm in subsequent years. Small-bowel biopsies at diagnosis showed subtotal villous atrophy (Marsh IIIb) in 18 (72%) and partial villous atrophy (Marsh IIIa) in seven (28%) patients. Repeat biopsy at 1-2 years showed shift from subtotal to partial villous atrophy in 94% (n = 17/18) and normalization in one patient. In patients with Marsh IIIa improvement of partial villous atrophy was observed in all. Immunoglobulin A endomysial antibody was negative in 81%. Repeat biopsies at 5 years of GFD showed improvement to Marsh I-II, but none normalized. Conclusion: The majority of children with CD show normalization of nutrition and growth after GFD. Small-bowel histology improves markedly but does not normalize even after 5 years of GFD.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Antibody; Celiac; Child; Gluten-free Diet; Growth; Histology
ID Code:4021
Deposited On:13 Oct 2010 07:11
Last Modified:30 Dec 2010 11:44

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