Modulation of autoimmune diseases by nitric oxide

Singh, Vijay K. ; Mehrotra, Shikhar ; Narayan, Prem ; Pandey, Chandra M. ; Agarwal, Shyam S. (2000) Modulation of autoimmune diseases by nitric oxide Immunologic Research, 22 (1). pp. 1-19. ISSN 0257-277X

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Nitric oxide (NO) is an intercellular messenger that performs a number of functions, including neurotransmission, vasodilatation, inhibition of platelet aggregation, and modulation of leukocyte adhesion. NO has recently been shown to act as a potent cytotoxic effector molecule as well as to play an important role in the pathogenesis of organ-specific autoimmunity. NO may also modulate the immune response by interfering with Th1/Th2 balance in autoimmune diseases. This review will discuss the role of NO and nitric oxide synthase (NOS) in pathophysiologic and therapeutic implications in various autoimmune diseases with particular reference to T helper- 1 (Th1) and T helper- 2 (Th2) cytokines.

Item Type:Article
Source:Copyright of this article belongs to Springer-Verlag.
Keywords:Autoimmunity; Immunomodulation; Nitric Oxide; Th1/Th2 Cytokines
ID Code:40
Deposited On:16 Sep 2010 09:14
Last Modified:11 May 2011 07:49

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