Genome-wide expression profile of steroid response in Saccharomyces cerevisiae

Banerjee, Dibyendu ; Pillai, Beena ; Karnani, Neerja ; Mukhopadhyay, Gauranga ; Prasad, Rajendra (2004) Genome-wide expression profile of steroid response in Saccharomyces cerevisiae Biochemical and Biophysical Research Communications, 317 (2). pp. 406-413. ISSN 0006-291X

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/s00062...

Related URL: http://dx.doi.org/10.1016/j.bbrc.2004.03.053

Abstract

The response of the yeast Saccharomyces cerevisiae to human steroid hormone progesterone was studied by genomic expression profiling. The transcription profile data revealed that steroid response was a global phenomenon wherein a host of genes were affected. For example, 163 genes were upregulated and 40 genes were downregulated, by at least more than twofold. The major categories of upregulated genes included protein destination (15%), metabolism (14%), transport facilitation (12%), cell growth, cell division, and DNA synthesis (8%), and transcription (7%), while metabolism (22%), transcription (11%), intracellular transport (10%), cell growth, cell division, and DNA synthesis (10%), energy (8%), cell rescue, defense, and cell death (6%), and protein synthesis (6%) encoding genes were downregulated. Notwithstanding the fact that yeast cells do not possess commonly occurring steroid response cascade similar to higher eukaryotes, our results demonstrate that a short-term exposure to progesterone results in differential regulation of predominantly stress responsive genes.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Saccharomyces cerevisiae; Stress Response; Progesterone; Estradiol; Steroid Response Element; Microarray; Profiling
ID Code:39351
Deposited On:12 May 2011 05:18
Last Modified:12 May 2011 05:18

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