Complete inventory of ABC proteins in human pathogenic yeast, Candida albicans

Gaur, Manisha ; Choudhury, Devapriya ; Prasad, Rajendra (2005) Complete inventory of ABC proteins in human pathogenic yeast, Candida albicans Journal of Molecular Microbiology and Biotechnology, 9 (1). pp. 3-15. ISSN 1464-1801

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The recent completion of the sequencing project of the opportunistic human pathogenic yeast, Candida albicans (, led us to analyze and classify its ATP-binding cassette (ABC) proteins, which constitute one of the largest superfamilies of proteins. Some of its members are multidrug transporters responsible for the commonly encountered problem of antifungal resistance. TBLASTN searches together with domain analysis identified 81 nucleotide-binding domains, which belong to 51 different putative open reading frames. Considering that each allelic pair represents a single ABC protein of the Candida genome, the total number of putative members of this superfamily is 28. Domain organization, sequence-based analysis and self-organizing map-based clustering led to the classification of Candida ABC proteins into 6 distinct subfamilies. Each subfamily from C. albicans has an equivalent in Saccharomyces cerevisiae suggesting a close evolutionary relationship between the two yeasts. Our searches also led to the identification of a new motif to each subfamily in Candida that could be used to identify sequences from the corresponding subfamily in other organisms. It is hoped that the inventory of Candida ABC transporters thus created will provide new insights into the role of ABC proteins in antifungal resistance as well as help in the functional characterization of the superfamily of these proteins.

Item Type:Article
Source:Copyright of this article belongs to S. Karger AG.
Keywords:Candida albicans; ATP-binding Cassette Proteins; Antifungal Resistance
ID Code:39340
Deposited On:10 May 2011 12:08
Last Modified:10 May 2011 12:08

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