The Baylis-Hillman reaction: one-pot stereoselective synthesis of methyl (2E)-3-aryl-2-hydroxymethylprop-2-enoates

Basavaiah, Deevi ; Padmaja, Kisari ; Satyanarayana, Tummanapalli (2000) The Baylis-Hillman reaction: one-pot stereoselective synthesis of methyl (2E)-3-aryl-2-hydroxymethylprop-2-enoates Synthesis, 2000 (12). pp. 1662-1664. ISSN 0039-7881

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Official URL: http://www.thieme-connect.com/ejournals/abstract/s...

Related URL: http://dx.doi.org/10.1055/s-2000-8213

Abstract

A facile, simple and one-pot conversion of methyl 3-aryl-3-hydroxy-2-methylenepropanoates into methyl (2E)-3-aryl-2-hydroxymethylprop-2-enoates via the sequential treatment with acetic anhydride/trimethylsilyl trifluoromethanesulfonate (TMSOTf) and potassium carbonate/methanol is described.

Item Type:Article
Source:Copyright of this article belongs to Thieme Medical Publishers Inc.
Keywords:Baylis-Hillman Reaction; Trimethylsilyl Trifluoromethanesulfonate (TMSOTF); Methyl (2E)-3-aryl-2-hydroxymethylprop-2-enoates; One-pot Stereoselective Synthesis
ID Code:3930
Deposited On:18 Oct 2010 09:25
Last Modified:18 Oct 2010 09:25

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