Biswas, Sonali ; Talukder, Geeta ; Sharma, Archana (1999) Protection against cytotoxic effects of arsenic by dietary supplementation with crude extract of Emblica officinalis fruit Phytotherapy Research, 13 (6). pp. 513-516. ISSN 0951-418X
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1...
Related URL: http://dx.doi.org/10.1002/(SICI)1099-1573(199909)13:6<513::AID-PTR525>3.0.CO;2-6
Abstract
Dietary administration of a crude aqueous extract of Emblica officinalis Gaertn. fruit reduced significantly the cytotoxic effects of sodium arsenite administered orally. The crude extract (685 mg/kg bw) was given daily by gavaging to age and sex matched laboratory bread Swiss albino mice for 7 and 14 days, followed by a single dose of sodium arsenite (2.5 mg/kg bw = 1/10 of LD50). The animals were killed after 24 h and chromosome preparations made following a schedule of colchicine-fixative-air drying-Giemsa. The endpoints screened were chromosomal aberrations and damaged cells. The crude extract reduced arsenic damage bringing the cells almost to the normal level.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Emblica officinalis Gaertn. Fruit Extract; Protection Against Arsenic; Chemoprevention; Clastogenic Effects |
| ID Code: | 39034 |
| Deposited On: | 06 May 2011 09:48 |
| Last Modified: | 06 May 2011 09:48 |
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