Inhibition of clastogenic effects of nicotine by chlorophyllin in mice bone marrow cells in vivo

Sen, Soumitra ; Sharma, Archana ; Talukder, Geeta (1991) Inhibition of clastogenic effects of nicotine by chlorophyllin in mice bone marrow cells in vivo Phytotherapy Research, 5 (3). pp. 130-133. ISSN 0951-418X

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/ptr.265...

Related URL: http://dx.doi.org/10.1002/ptr.2650050309

Abstract

The effect of chlorophyllin in modifying the clastogenic action of nicotine was tested in vivo on mice bone marrow cells. Nicotine, when administered by gavage, induced chromosomal aberrations in frequencies directly proportional to the dose. Maximum effects were recorded at 6 h after exposure. Chlorophyllin, when given alone, was not clastogenic even at the highest concentration (1.50 mg/kg body wt). Simultaneous administration of nicotine and chlorophyllin with even lower doses (1.25 and 0.77 mg/kg body wt) reduced the frequency of chromosomal aberrations to the normal level. Chlorophyllin alone, given 2 h before nicotine, however, did not counteract the effects of nicotine. The use of green plant parts in modifying the genotoxicity of different agents may be related to the protective action of chlorophyllin.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Chlorophyllin; Nicotine; Anticlastogens; Mice Bone Marrow Chromosomes
ID Code:39025
Deposited On:06 May 2011 09:29
Last Modified:06 May 2011 09:29

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