Expression of Hb β-T and Hb β-E genes in Eastern India - Family studies

Ajmani, Manju ; Talukder, Geeta ; Sharma, Archana ; Bhattacharya, D. K. (1981) Expression of Hb β-T and Hb β-E genes in Eastern India - Family studies Journal of Biosciences, 3 (2). pp. 191-196. ISSN 0250-5991

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The distribution patterns of different haemoglobins were observed amongst the family members of β-thalassaemia homozygous and HbE-β-thalassaemia patients with the aid of gel electrophoretic and alkali denaturation techniques. Of the 18 families studied, four belonged to β-thalassaemia homozygous and 14 to HbE-β-thalassaemia patients. Interaction of HbE and β-thalassaemia genes resulted in major clinical abnormalities with increase in the percentages of haemoglobins F and E. The percentages of HbA2 in homozygous β-thalassaemia were within the normal range. Although in Southeast Asia the β° type of HbE-thalassaemia is more prevalent, only one individual with this type of thalassaemia was observed during this survey. In the rest of the patients examined the percentages of adult haemoglobin ranged from 5.2 to 42.5 indicating the presence of a β+ type gene.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:β-thalassaemia; Haemoglobin E; Haemoglobin A
ID Code:39012
Deposited On:05 May 2011 14:14
Last Modified:17 May 2016 21:37

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