Cytotoxicity of zinc chloride in mice in vivo

Gupta, Tarun ; Talukder, Geeta ; Sharma, Archana (1991) Cytotoxicity of zinc chloride in mice in vivo Biological Trace Element Research, 30 (2). pp. 95-101. ISSN 0163-4984

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Intraperitoneal administration of zinc chloride (ZnCl2) to Swiss albino mice in vivo induced a significant (p≤0.05) increase in the frequencies of chromosomal aberrations of the bone-marrow cells at all concentrations used following acute (7.5, 10, 15 mg/kg body weight) and chronic (2.0, 3.0 mg/kg body wt) treatment. The degree of clastogenicity was directly proportional to the concentrations (p≤0.05, trend test) and indirectly to the period of treatment (p≤0.05, ANOVA test). It induced a dose-dependent, statistically significant increase (Mann-Whitney U statistics, student'st-test) in sperm-head abnormalities. The data designate ZnCl2 as a potent clastogen and as a toxic chemical at the concentrations used.

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ID Code:38998
Deposited On:05 May 2011 13:52
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