Ghosh, Sujita ; Sharma, Archana ; Talukder, Geeta (1991) Relationship of clastogenic effects of zirconium oxychloride to dose and duration of exposure in bone marrow cells of mice in vivo Toxicology Letters, 55 (2). pp. 195-201. ISSN 0378-4274
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/037842...
Related URL: http://dx.doi.org/10.1016/0378-4274(91)90134-R
Abstract
Zirconium oxychloride was administered as a single oral dose to laboratory-bred Swiss albino mice corresponding to ½, ⅙ and 1/20 of the LD50 values. Bone marrow cells were screened after 6, 12 and 24 h for chromosomal aberrations following an air-drying-Giemsa schedule. The frequencies of chromosomal breaks and alterations induced increased significantly at a rate directly proportional to the concentration used. The increase was also related to the period after exposure, although to a less extent than the concentration used. No direct relationship could be observed to the sex of the animal.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Metal Clastogenicity; Chromosomal Aberrations |
| ID Code: | 38981 |
| Deposited On: | 05 May 2011 13:34 |
| Last Modified: | 05 May 2011 13:34 |
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