Prevention of cytotoxic effects of arsenic by short-term dietary supplementation with selenium in mice in vivo

Biswas, Sonali ; Talukder, Geeta ; Sharma, Archana (1999) Prevention of cytotoxic effects of arsenic by short-term dietary supplementation with selenium in mice in vivo Mutation Research: Genetic Toxicology and Environmental Mutagenesis, 441 (1). pp. 155-160. ISSN 1383-5718

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S13835...

Related URL: http://dx.doi.org/10.1016/S1383-5718(99)00028-5

Abstract

Interaction between selenium and arsenic has been used to protect against the genotoxic effects of sodium arsenite through dietary intervention by an equivalent amount (1/10 LD50) of sodium selenite. The two salts were administered by gavaging to laboratory bred Swiss albino mice sequentially and in combination. Cytogenetic endpoints, including chromosomal aberrations (CA) and damaged cells (DC) were recorded 24 h after exposure from chromosome spreads in bone marrow cells. Administration of sodium selenite 1 h before sodium arsenite reduced the clastogenic effects of the latter significantly. The protection was less when the salts were given together and negative when arsenite was given before selenite. Histological changes were recorded. Such reduction of arsenic toxicity through dietary intervention by selenium is of significance in protecting against the widespread toxicity observed in human populations exposed to arsenic through drinking water from contaminated deep tubewells in West Bengal and Bangladesh.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Arsenic Cytotoxicity; Arsenic-selenium Interaction; Dietary Intervention
ID Code:38975
Deposited On:05 May 2011 13:24
Last Modified:11 May 2011 12:36

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