Choudhury, Arati Roy ; Das, Tandra ; Sharma, Archana ; Talukder, Geeta (1997) Inhibition of clastogenic effects of arsenic through continued oral administration of garlic extract in mice in vivo Mutation Research: Genetic Toxicology and Environmental Mutagenesis, 392 (3). pp. 237-242. ISSN 1383-5718
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S13835...
Related URL: http://dx.doi.org/10.1016/S1383-5718(97)00076-4
Abstract
Crude aqueous extract of garlic bulbs (Allium sativum L. single clove variety) was administered by gavage to mice of both sexes daily for up to 30 and 60 days, in doses corresponding to 6 g for a 60 kg human body. Sodium arsenite (at 1/50 of LD50 dose) was injected subcutaneously to mice on every 7th day of the experiment. Chromosome preparations made from bone marrow following flame drying Giemsa schedule were screened for chromosomal aberrations. The clastogenic affects of prolonged exposure to sodium arsenite-a strong clastogen-was reduced by a highly significant amount when crude garlic extract, in the dose used, was given daily to the mice by intubation for the same period.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Arsenic Clastogenicity; Anticlastogenic Effects of Garlic; Dietary Supplement |
| ID Code: | 38969 |
| Deposited On: | 05 May 2011 13:16 |
| Last Modified: | 05 May 2011 13:16 |
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