Synthetic studies towards glycopeptide antibiotics: synthesis of the 16-membered cyclic tripeptide (DOEG ring) system of teicoplanin

Rama Rao, A. V. ; Laxma Reddy, K. ; Srinivasa Rao, A. ; Vittal, T. V. S. K. ; Reddy, M. M. ; Pathi, P. L. (1996) Synthetic studies towards glycopeptide antibiotics: synthesis of the 16-membered cyclic tripeptide (DOEG ring) system of teicoplanin Tetrahedron Letters, 37 (17). pp. 3023-3026. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/004040...

Related URL: http://dx.doi.org/10.1016/0040-4039(96)00459-5

Abstract

The synthesis of the 16-membered cyclic DOEG ring system of teicoplanin, which forms the binding pocket for the carboxylate region of terminal D-Ala-D-Ala of the bacterial cell wall via macroetherification of linear tripeptide 20 is described.

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