Applications of Baylis-Hillman acetates: one-pot, facile and convenient synthesis of substituted γ-lactams

Basavaiah, Deevi ; Rao, Jamjanam Srivardhana (2004) Applications of Baylis-Hillman acetates: one-pot, facile and convenient synthesis of substituted γ-lactams Tetrahedron Letters, 45 (8). pp. 1621-1625. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2003.12.133

Abstract

A simple, convenient and one-pot transformation of the acetates of Baylis-Hillman adducts into substituted γ-lactams, that is, (E)-5-alkyl-3-arylidenepyrrolidin-2-ones via treatment with nitroalkanes in the presence of a base, followed by reductive cyclization, using Fe/AcOH, is described.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Baylis-Hillman Chemistry; γ-lactams; Reductive Cyclization; Fe/AcOH
ID Code:3853
Deposited On:18 Oct 2010 09:36
Last Modified:18 Oct 2010 09:36

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