Chemical amplification - a novel approach to ultratrace analysis

Rajagopalan, S. R. (1983) Chemical amplification - a novel approach to ultratrace analysis Bulletin of Materials Science, 5 (3-4). pp. 317-322. ISSN 0250-4707

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The lowest concentration that can be estimated with 100% error in chemical analysis by instrumental technique is referred to as detection limit. It is equal to the ratio of twice the background signal to the magnitude of analytical signal corresponding to a concentration of unity. Detection limit (DL) could be improved if the analytical signal alone could be selectively amplified without affecting the background. It is shown that this could be achieved by chemical amplification. Atomic amplification of two or three orders of magnitude could be obtained by combining two chemical amplifications in series. It is demonstrated that by using heteropoly acid formation as the first amplification reaction and determining molybdenum in the heteropoly acid by catalyticdc polarographic wave, a detection limit for the hetero atom of less than a ppb can be obtained. It is pointed out that the approach of selectively amplifying analytical signals by tandem chemical amplification reactions makes it possible to perform ultratrace analysis (ppb level) with classical instrumental analytical techniques which have DL at ppm level.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Chemical Amplification; Trace Analysis; Ultratrace Analysis; DC Polarography; Signal-to-background Ratio
ID Code:38361
Deposited On:29 Jun 2011 13:02
Last Modified:17 May 2016 21:15

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