Bhaskar Kanth, J. V. ; Periasamy, Mariappan (1993) Convenient method for the synthesis of chiral α,α-diphenyl-2-pyrrolidinemethanol Tetrahedron, 49 (23). 5127-5132 . ISSN 0040-4020
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...
Related URL: http://dx.doi.org/10.1016/S0040-4020(01)81877-9
Abstract
A simplified, convenient synthesis of chiral α,α-diphenyl-2-pyrrolidine-methanol involving one step N-and O-protection of S-proline using ethylchloroformate followed by Grignard addition-alkaline hydrolysis (KOH/CH3OH) is described. Chiral α, α-diphenyl-2-pyrrolidinemethanol S-1, is synthesised from S-proline utilizing inexpensive reagents, following a method involving only two isolation procedures.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 36998 |
| Deposited On: | 25 Apr 2011 08:03 |
| Last Modified: | 25 Apr 2011 08:03 |
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