A study on the effects of cyclo-oxygenase and thromboxane synthetase inhibitors on right atrial prostacyclin and thromboxane A2 levels

Madan, Zinobia M. ; Sainani, G. S. ; Parulkar, G. B. (1996) A study on the effects of cyclo-oxygenase and thromboxane synthetase inhibitors on right atrial prostacyclin and thromboxane A2 levels Indian Journal of Thoracic and Cardiovascular Surgery, 12 (1-2). pp. 7-10. ISSN 0970-9134

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Official URL: http://www.springerlink.com/content/q3m332124773v4...

Related URL: http://dx.doi.org/10.1007/BF02863205

Abstract

The right atrial tissues obtained at the time of coronary bypass surgery were studied for release of prostacyclin and thromboxane. Human, right atrial tissues are capable of producing thromboxane A2 (TXA2) in addition to prostacyclin. Indomethacin and Aspirin by inhibiting generation of cyclic endoperoxides inhibited synthesis of both prostacyclin and TXA2 In contrast a thromboxane synthethase inhibitor U63557A selectively inhibited TXA2 without significant effects on prostacyclin synthesis. The study points to the superiority of thromboxane synthetase inhibitor U63557A over Aspirin or Indomethacin and represents an important approach to platelet inhibition by selectively inhibiting thromboxane synthesis without affecting the synthesis of prostacycline.

Item Type:Article
Source:Copyright of this article belongs to Indian Association of Cardiovascular-Thoracic Surgeons.
ID Code:36661
Deposited On:09 Apr 2011 12:33
Last Modified:09 Apr 2011 12:33

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