Ability of human chorionic gonadotropin β-subunit to inhibit the steroidogenic response to lutropin

Dighe, R. R. ; Muralidhar, K. ; Moudgal, N. R. (1979) Ability of human chorionic gonadotropin β-subunit to inhibit the steroidogenic response to lutropin Biochemical Journal, 180 . pp. 573-578. ISSN 0264-6021

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Official URL: http://www.biochemj.org/bj/180/bj1800573.htm

Abstract

Ability of the β-subunit of human chorionic gonadotropin to inhibit the response to lutropin (luteinizing hormone, LH) was tested in the immature rat ovarian system and pregnant-mare-serum-gonadotropin-primed rat ovarian system with progesterone production being used as the response. Human chorionic gonadotropin β-subunit was found to inhibit human and ovine lutropin-stimulated progesterone production. At a constant dose of lutropin, inhibition was dependent on the concentration of β-subunit. When concentration of the β-subunit was kept constant at 5.0 μg/ml and the concentration of lutropin was varied, the inhibition was maximum at the saturating concentration of the native hormone. The α-subunit of the human chorionic gonadotropin did not inhibit the response to lutropin. The lutropin/β-subunit ratio required to produce an inhibition of response was much lower than that required to bring about an observable inhibition of binding.

Item Type:Article
Source:Copyright of this article belongs to Portland Press.
ID Code:36067
Deposited On:14 Apr 2011 14:09
Last Modified:17 May 2016 19:01

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