Radiovaccine of S. typhimurium cells

Nerkar, D. P. ; Govekar, L. G. ; Kumta, U. S. ; Sreenivasan, A. (1977) Radiovaccine of S. typhimurium cells International Journal of Radiation Biology, 31 (4). pp. 335-340. ISSN 0955-3002

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Gamma-irradiation of S. typhimurium cells up to a dose of 500 krad significantly reduces their toxicity. However, the antigenicity of these cells is not altered, which suggests that these cells could be used as a vaccine. The protection offered by the irradiated cells is comparable to that of formalin-treated cells, The radio-vaccine, however, offers an additional advantage of significant detoxification of the endotoxin, thereby minimizing side effects. The lipopoly-saccharide extracted from the irradiated S. typhimurium cells offered cross-protection against other Salmonella species tested.

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