Protective action of vitamin B12 in the hyperthyroid rat

Lavate, W. V. ; Sreenivasan, A. (1956) Protective action of vitamin B12 in the hyperthyroid rat Nature, 178 (4537). pp. 804-805. ISSN 0028-0836

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Official URL: http://www.nature.com/nature/journal/v178/n4537/ab...

Related URL: http://dx.doi.org/10.1038/178804a0

Abstract

The protection afforded by vitamin B12 against thyrotoxicosis in the rat was explained as due to a restoration in part of the uncoupling of oxidative phosphorylation caused by thyroxine. Since it is known that osmotic damage to mitochondria could cause a diminution in oxidative phosphorylation, the possibility was considered that in hyperthyroidism there may be an altered distribution of vitamin B12 in the cell fractions.

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