Cobalt toxicity and iron metabolism in Neurospora crassa

Padmanaban, G. ; Sarma, P. S. (1966) Cobalt toxicity and iron metabolism in Neurospora crassa Biochemical Journal, 98 (1). pp. 330-334. ISSN 0264-6021

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1. Increasing concentrations of cobalt in the medium result in increased production of an iron-binding compound and a corresponding fall in catalase activity of Neurospora crassa. 2. Cobalt rapidly depletes the medium of iron by enhancing the rate of iron uptake by the mycelium. 3. With toxic amounts of cobalt there is a fall in bound 59Fe and haem 59Fe as well as a decreased incorporation of [2-14C]glycine into the mycelial haem fraction. The production of the iron-binding compound precedes the fall in the iron-dependent systems mentioned. 4. The 59Fe bound to the iron-binding compound acts as a better iron source for haem synthesis in cell-free extracts as compared with 59FeSO4. 5. Cobalt inhibits iron incorporation into protoporphyrin in cell-free extracts but is not itself incorporated to an appreciable extent.

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