DNAase-I-hypersensitive sites in the mouse albumin gene

Parnaik, Veena K. (1987) DNAase-I-hypersensitive sites in the mouse albumin gene Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 910 (1). pp. 27-33. ISSN 0167-4781

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/016747...

Related URL: http://dx.doi.org/10.1016/0167-4781(87)90091-1


We have analyzed the DNAase I sensitivity of the mouse α-fetoprotein and albumin structural genes from fetal liver, adult liver and kidney. The albumin gene shows distinct hypersensitive sites in adult liver in addition to an overall DNAase I sensitivity, but is only slightly nuclease-sensitive in fetal liver. The α-fetoprotein gene does not show hypersensitive sites but displays an overall DNAase I sensitivity in fetal liver; however, it is nuclease-insensitive in adult liver. Both genes are insensitive to DNAase I in kidney. The presence of DNAase-I-hypersensitive sites in the albumin structural gene correlates with extensive demethylation of the gene in adult liver.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Chromatin; α-Fetoprotein Gene; Albumin Gene; Nuclease-sensitive Site; Transcription; DNA Methylation
ID Code:34783
Deposited On:11 Apr 2011 14:00
Last Modified:11 Apr 2011 14:00

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