Identification of cyclin D3 as a new interaction partner of lamin A/C

Mariappan, Indumathi ; Gurung, Ritika ; Thanumalayan, Subramonian ; Parnaik, Veena K. (2007) Identification of cyclin D3 as a new interaction partner of lamin A/C Biochemical and Biophysical Research Communications, 355 (4). pp. 981-985. ISSN 0006-291X

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00062...

Related URL: http://dx.doi.org/10.1016/j.bbrc.2007.02.060

Abstract

Lamin A/C is a major component of the nuclear lamina. An intact nuclear lamina has been proposed to be necessary for muscle differentiation. Cyclin D3 is known to be upregulated in differentiated muscle cells and to form insoluble complexes with cell-cycle regulatory factors in these cells. We have examined the possibility of direct binding interactions between lamin A/C and cyclin D3 by in vitro binding assays and co-immunoprecipitation studies with muscle cells. Our results indicate that cyclin D3 binds specifically to amino acid residues 383–474 of lamin A/C and associates with lamin A/C in muscle cells. The identification of cyclin D3 as a novel binding partner of lamin A/C has important implications for a role for lamin A/C in muscle differentiation.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Nuclear Lamina; Lamin A; Cyclin D3; Muscle Differentiation
ID Code:34768
Deposited On:11 Apr 2011 14:09
Last Modified:17 May 2016 17:39

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