Hamid, Q. Anwar ; Fatima, Soghra ; Thanumalayan, Subramonian ; Parnaik, Veena K. (1996) Activation of the lamin A gene during rat liver development FEBS Letters, 392 (2). pp. 137-142. ISSN 0014-5793
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/001457...
Related URL: http://dx.doi.org/10.1016/0014-5793(96)00802-2
Abstract
We have studied the regulation of expression of the A-type lamins, which are constituents of the nuclear lamina. During rat liver development, high levels of lamin A and C mRNAs were observed in 15-day fetal liver but were barely detectable in the adult. The chromatin conformation of the lamin A gene was sensitive to DNase I in 15-day fetal liver but became mostly insensitive in the adult. Lamin A and C proteins could be detected in fetal liver and persisted in the adult. Our evidence suggests that the lamin A gene is actively transcribed early in liver differentiation and its activity declines considerably in adult liver.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Lamin A Gene; Nuclear Lamina; Liver Development |
| ID Code: | 34730 |
| Deposited On: | 11 Apr 2011 14:01 |
| Last Modified: | 11 Apr 2011 14:01 |
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