Anomalous dispersion method: its power for protein structure analysis

Ramachandran, G. N. ; Parthasarathy, S. (1965) Anomalous dispersion method: its power for protein structure analysis Science, 150 (3693). pp. 212-214. ISSN 0036-8075

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Official URL: http://www.sciencemag.org/content/150/3693/212.abs...

Related URL: http://dx.doi.org/10.1126/science.150.3693.212

Abstract

The phases of X-ray reflection of a crystal can be measured, except for an ambiguity, if the crystal contains heavy atoms which scatter X-rays anomalously. Theoretical studies show that the method of resolving this ambiguity by choosing the phases closer to those of the heavy atoms has a good potentiality for solving complicated structures, in which the average heavy atom contribution to the intensity is as low as 10 percent.

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