Crystalline constituents of euphorbiaceae-VI: The synthesis and absolute configuration of phyllanthin

Row, L. R. ; Satyanarayana, P. ; Subba Rao, G. S. R. (1967) Crystalline constituents of euphorbiaceae-VI: The synthesis and absolute configuration of phyllanthin Tetrahedron, 23 (4). pp. 1915-1918. ISSN 0040-4020

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4020(01)82594-1

Abstract

(+)Phyllanthin is now shown to be (8S, 8′S) 3,4,3′,4′,9,9′-hexamethoxy-8-8′-butyrolignan (III) by its synthesis from (a) (−)eudesmin (I) and (b) (+)2,3-diveratryl succinic acid (IV). (+)3,4-diveratryl tetrahydrofuran (VI) from (+)phyllanthin is now shown to posses 3S,4S configuration by its formation from (+)2,3-diveratryl-1,4-butane diol (II).

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