Nagarajan, Kuppuswamy ; David, Joy ; Shah, Rashmi K. (1976) Central nervous system active 5-oxo-1,4,5,6,7,8-hexahydrocinnolines Journal of Medicinal Chemistry, 19 (4). pp. 508-511. ISSN 0022-2623
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Official URL: http://pubs.acs.org/doi/abs/10.1021/jm00226a012
Related URL: http://dx.doi.org/10.1021/jm00226a012
Abstract
Among a series of 5-oxo-1,4,5,6,7,8-hexahydrocinnolines examined for their CNS activity, 1-(2-diethylaminoethyl)-3-(p-fluorophenyl)-5-oxo-7,7-dimethyl-1,4,5,6,7,8-hexahydrocinnoline (23) and 1-(2-dimethylaminoethyl)-3-phenyl-5-oxo-7,7-dimethyl-1,4,5,6,7,8-hexahydrocinnoline (27) had sedative and anticonvulsant properties and were also acitve in tests used to characterize antidepressants. But their narrow safety margin precluded further follow-up studies. Derivatives 35-38 of 2-(omega-phenacyl)-3-hydrazino-5,5-dimethyl-2-cyclohexenone were active in tests used to characterize antidepressants and were weakly sedative but not anticonvulsant.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 33491 |
| Deposited On: | 21 Mar 2011 14:20 |
| Last Modified: | 21 Mar 2011 14:20 |
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