Urinary excretion of hydroxyproline in leprosy

George Cherian, M. ; Karat, A. B. A. ; Radhakrishnan, A. N. (1969) Urinary excretion of hydroxyproline in leprosy Clinica Chimica Acta, 25 (3). pp. 395-401. ISSN 0009-8981

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000989...

Related URL: http://dx.doi.org/10.1016/0009-8981(69)90198-3

Abstract

Urinary excretion of hydroxyproline has been studied in patients with different types of leprosy. The mean average daily excretion is highest in lepromatous leprosy as compared with other forms of leprosy or normal controls. The most striking feature is the "spiky" pattern of the excretion with very wide fluctuations in the daily output observed in lepromatous leprosy patients in reaction. This pattern was not seen in similar investigations in patients with a stable form of leprosy and in a normal subject. The increase in hydroxyproline excretion in lepromatous leprosy was observed in both urinary hydroxyproline fractions studied (HP Fraction 1 and HP Fraction 2) but the increase in HP Fraction 2 was more significant.

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