Bagwe, Aparna N. ; Ganu, Ulhas K. ; Gokhale, Shreekant V. ; Bhisey, Rajani A. (1990) Evaluation of the mutagenicity of 'pan masala', a chewing substitute widely used in India Mutation Research/Genetic Toxicology, 241 (4). pp. 349-354. ISSN 0165-1218
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/016512...
Related URL: http://dx.doi.org/10.1016/0165-1218(90)90064-9
Abstract
Mutagenicity of polar and non-polar extracts of a popular brand of 'pan masala' was examined using the Salmonella/mammalian microsome test (Ames assay) and 2 tester strains of Salmonella typhimurium, TA98 and TA100. These extracts were also subjected to pretreatment with sodium nitrite at acidic pH, to simulate conditions for endogenous nitrosation. The equeous, aqueous: ethanolic and chloroform extracts as well as their nitrosated mixtures were non-mutagenic in the Ames assay, in the presence and absence of metabolic activation. Only the ethanolic extract elicited a weak mutagenic response in strain TA98 without metabolic activation demonstrating the presence of direct-acting frameshift mutagens in 'pan masala'.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | 'Pan Masala'; Polar and Non-polar Extracts; Mutagenicity; Ames Assay |
| ID Code: | 3233 |
| Deposited On: | 11 Oct 2010 09:55 |
| Last Modified: | 27 May 2011 09:33 |
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