Partial molal heat capacity of the peptide group in aqueous solutions

Mishra, A. K. ; Ahluwalia, J. C. (1981) Partial molal heat capacity of the peptide group in aqueous solutions International Journal of Peptide and Protein Research, 18 (5). pp. 506-512. ISSN 0367-8377

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Integral enthalpies of solution at very high dilution of sodium salts of N-acetyl amino acids, N-acetyl peptides, and N-benzoyl glycine have been measured in water at 298.15 and 308.15 K. Standard heat capacities of solution at 303.15 K have been derived from the enthalpy of solution data. The peptide backbone-unit (CH2CONH) contribution toward the limiting partial molal heat capacities derived from these experimental results is compared with those obtained from Cp2 of other model compounds, viz. oligopeptides, pyrrolidones, piperidones, diketopiperazine, and amides. Cp2 of the peptide backbone unit observed in the sodium salts of the Nu-substituted amino acids and peptides is also correlated with the structural details of the compounds and it is concluded that Cp2 contribution of the whole CH2CONH group, rather than that of CONH group, should be used for predicting the heat capacities of polypeptides and proteins in aqueous solution.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Aqueous Solution of Peptides; Enthalpy of Solution of Peptides; Hydration of Peptides; Model Compounds; Partial Molal Heat Capacity of Peptides; Partial Molal Heat Capacity of Peptide Group
ID Code:319
Deposited On:21 Sep 2010 04:49
Last Modified:11 May 2011 07:22

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