Development of auxotrophy by streptomycin-resistant mutation

Chakrabarti, S. L. ; Maitra, P. K. (1974) Development of auxotrophy by streptomycin-resistant mutation Journal of Bacteriology, 118 (3). pp. 1179-1180. ISSN 0021-9193

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Several streptomycin-resistant mutants of Escherichia coli have been isolated which require exogenous isoleucine for growth. The majority of these strains were of streptomycin-dependent phenotype. If grown in the absence of streptomycin, these streptomycin-dependent auxotrophs (Smd-aux) strains were unable to produce β-galactosidase and aldolase activities and also failed to exhibit donor properties in conjugation. Genetic analysis indicated that the isoleucine requirement of these strains could be caused by a mutation at the strA locus.

Item Type:Article
Source:Copyright of this article belongs to American Society for Microbiology.
ID Code:31526
Deposited On:25 Apr 2011 09:25
Last Modified:17 May 2016 14:13

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