Lipoic acid and diabetes II: Mode of action of lipoic acid

Gandhi, V. M. ; Wagh, S. S. ; Natraj, C. V. ; Menon, K. K. G. (1985) Lipoic acid and diabetes II: Mode of action of lipoic acid Journal of Biosciences, 9 (1-2). pp. 117-127. ISSN 0250-5991

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Intraperitoneal administration of lipoic acid (10 mg/100 g) does not effect changes in serum insulin levels in normal and alloxan diabetic rats, while normalising increased serum pyruvate, and impaired liver pyruvic dehydrogenase characteristic of the diabetic state. Dihydrolipoic acid has been shown to participate in activation of fatty acids with equal facility as coenzyme A. Fatty acyl dihydrolipoic acid however is sparsely thiolyzed to yield acetyl dihydrolipoic acid. Also acetyl dihydrolipoic acid does not activate pyruvate carboxylase unlike acetyl coenzyme A. The reduced thiolysis of β-keto fatty acyl dihydrolipoic acid esters and the lack of activation of pyruvic carboxylase by acetyl dihydrolipoic acid could account for the antiketotic and antigluconeogenic effects of lipoic acid.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Lipoic Acid; Diabetes; Acetyl Coenzyme A; Acetyl Dihydro Lipoic Acid; Fatty Acid Oxidation; Gluconeogenesis
ID Code:31488
Deposited On:11 Mar 2011 09:35
Last Modified:17 May 2016 14:10

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