Experiences with intra-arterial chemotherapy for head and neck cancer

Jussawalla, D. J. ; Shetty, P. A. (1978) Experiences with intra-arterial chemotherapy for head and neck cancer Journal of Surgical Oncology, 10 (1). pp. 33-37. ISSN 0022-4790

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/jso.293...

Related URL: http://dx.doi.org/10.1002/jso.2930100106


During the 10-year period from 1966-1975, 250 patients with various head and neck cancers were treated by intra-arterial chemotherapy using single agents or various combinations. Only 15 patients showed response of I-C category according to Karnofsky's criteria, and 100 patients had I-B response. Another 100 patients showed I-A category of response and 35 patients had progressive disease out of which 5 patients exhibited excessive toxicity to drugs, eventually succumbing to it. A majority of patients in nonresponding (O-O) category and I-A category were earlier treated by radiotherapy, and intra-arterial chemotherapy was given for recurrent disease. The responses were relatively good whenever chemotherapy was given as a primary treatment before surgery and radiotherapy. Again response was additive when chemotherapy was given concurrently with radiotherapy.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Head and Neck Cancer; Chemotherapy; Intra-arterial
ID Code:31487
Deposited On:10 Mar 2011 05:21
Last Modified:13 Aug 2011 09:55

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