Mode of action of lipoic acid in diabetes

Wagh, S. S. ; Natraj, C. V. ; Menon, K. K. G. (1987) Mode of action of lipoic acid in diabetes Journal of Biosciences, 11 (1-4). pp. 69-74. ISSN 0250-5991

[img]
Preview
PDF - Publisher Version
445kB

Official URL: http://www.ias.ac.in/jarch/jbiosci/11/59-74.pdf

Related URL: http://dx.doi.org/10.1007/BF02704658

Abstract

Metabolic aberrations in diabetes such as hyperglycemia, ketonemia, ketonuria, reduced glycogen in tissues and reduced rates of fatty acid synthesis in the liver are corrected by the administration of lipoic acid. Dithiol octanoic acid is formed from lipoic acid by reduction and substitutes for Coenzyme A in several enzymatic reactions such as pyruvate dehydrogenase, citrate synthase, acetyl Coenzyme A carboxylase, fatty acid synthetase, and triglyceride and phospholipid biosynthesis; but not in the oxidation of fatty acids because of the slow rates of thiolysis of β-keto acyl dithioloctanoic acid. The overall effect of these changes in the key enzymic activities is seen in the increased rates of oxidation of glucose and a reduction in fatty acid oxidation in diabetes following lipoic acid administration.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Lipoic Acid; Diabetes; Coenzyme A; Pyruvate Dehydrogenase; Lipid Biosynthesis; Acetoacetate Metabolism
ID Code:31486
Deposited On:11 Mar 2011 10:00
Last Modified:17 May 2016 14:09

Repository Staff Only: item control page