Ectopic production of human placental lactogen by human breast tumors

Sheth, Nandini A. ; Suraiya, Jayant N. ; Sheth, Anil R. ; Ranadive, Kamal J. ; Jussawalla, D. J. (1977) Ectopic production of human placental lactogen by human breast tumors Cancer, 39 (4). pp. 1693-1699. ISSN 0008-543X

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Serum samples from 72 patients with established carcinoma of the breast were investigated for ectopic presence of hPL. Further, the relationship of ectopically-secreted hPL and hCG-β in breast cancer was investigated. Ten of 72 patients examined had detectable hPL and 12 had detectable hCG-β, at 1-2 ng/ml serum sensitivity of the assay. The presence of hPL in serum of breast cancer patients was found to be independent of that of hCG-β. Sera of 13 patients with cystic mastitis, five with fibroadenoma, two with acute inflamation of breast, 20 normal women (non-pregnant) and 20 normal men did not show any detectable serum hPL or hCG-β at the above mentioned sensitivity of the assay. Since these hormones were not detectable in normal men, normal non-pregnant women, and in patients having other pathological conditions of breast, the possible use of them as markers in cancer is expected.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
ID Code:31430
Deposited On:08 Mar 2011 12:36
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