Mutations in the regulatory subunit of soluble phosphofructokinase from yeast

Nadkarni, Medha ; Parmar, Latika ; Lobo, Zita ; Maitra, P. K. (1984) Mutations in the regulatory subunit of soluble phosphofructokinase from yeast FEBS Letters, 175 (2). pp. 294-298. ISSN 0014-5793

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/001457...

Related URL: http://dx.doi.org/10.1016/0014-5793(84)80754-1

Abstract

Mutant alleles of the gene PFK2 have been obtained that alter the sensitivity to ATP inhibition of the soluble yeast phosphofructokinase. One of the alleles makes the enzyme sensitive to micromolar concentrations of ATP. Intragenic revertants of PFK2 mutants confirm that the PFK2 gene determines not only the regulatory properties of the soluble enzyme but also the catalytic activity of particulate phosphofructokinase.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Yeast Phosphofructokinase; Regulatory Subunit Mutant; Hyper-allostery; Pfk2 Gene Product; Particulate Phosphofructokinase; Phosphofructokinase Mutant
ID Code:31407
Deposited On:25 Apr 2011 09:27
Last Modified:17 May 2016 14:03

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