Rao, S. L. N. ; Sarma, P. S. ; Mani, K. S. ; Raghunatha Rao, T. R. ; Sriramachari, S. (1967) Experimental neurolathyrism in monkeys Nature, 214 (5088). pp. 610-611. ISSN 0028-0836
Full text not available from this repository.
Official URL: http://www.nature.com/nature/journal/v214/n5088/ab...
Related URL: http://dx.doi.org/10.1038/214610a0
Until now the cause of the relation between Lathyrus sativus and the spastic paraplegia, known as neurolathyrism, has been inferred purely on epidemiological grounds and neurotoxic manifestations with or without histopathological verification have not so far been obtained. The isolation and characterization of β-N-oxalyl-L-α,β-diaminopropionic acid (OX-Dapro), an unusual amino-acid, which was "neurotoxic" to 1 day old chicks have, however, been reported. We have found that intraperitoneal injection of this compound in adult chicks required a proportionately much larger dose to produce similar effects. An intraperitoneal or intravenous administration of this compound to adult rats at a level of 1 mg/g body weight or intraperitoneally in mice did not produce any symptoms, while administration of 25μg intracisternally was seen to produce convulsions. It was felt that this might be caused by an effective "blood-brain barrier" and thus we decided to investigate the effect of this compound when intrathecally injected into adult monkeys (Macaca radiata).
|Source:||Copyright of this article belongs to Nature Publishing Group.|
|Deposited On:||31 Mar 2011 13:54|
|Last Modified:||09 Jun 2011 13:43|
Repository Staff Only: item control page