Single daily dose chlorpromazine therapy in psychosis: an evaluation

Kalyanasundaram, S. ; Shrikhande, S. A. ; Machado, T. A. ; Kapur, R. L. (1981) Single daily dose chlorpromazine therapy in psychosis: an evaluation Acta Psychiatrica Scandinavica, 64 (2). pp. 158-166. ISSN 0001-690X

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A double blind study was undertaken to compare the efficacy of a single bedtime dose of chlorpromazine (300 mg) with divided doses of the same drug (100 mg, thrice daily). Brief Psychiatric Rating Scale (BPRS) and Nurses' Observation Scale for Inpatient Evaluation (NOSIE) were administered to 80 acutely psychotic patients who took part in the study. Thirty-one patients in the experimental and 29 in the control group completed this 3-week trial. It was observed that there were no statistically significant differences between the two modes of treatment. Drowsiness was seen more often in the single bedtime schedule. Postural hypotension was observed in both patient groups. The implications of single night-time medication in psychotics is discussed.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Chlorpromazine; Single Daily Dose; Drug Trial; Side Effects
ID Code:31099
Deposited On:28 Dec 2010 07:49
Last Modified:04 Jun 2011 09:44

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