Effect of cadmium on hepatic mixed-function oxidases during the early development of rats : possible protective role of metallothionein

Asokan, Parthasarathi ; Dixit, Rakesh ; Mukhtar, Hasan ; Krishna Murti, Coimbatore R. (1981) Effect of cadmium on hepatic mixed-function oxidases during the early development of rats : possible protective role of metallothionein Biochemical Pharmacology, 30 (22). pp. 3095-3097. ISSN 0006-2952

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...

Related URL: http://dx.doi.org/10.1016/0006-2952(81)90498-6

Abstract

Hepatic metallothionein contents and activities of mixed function oxidases in control and cadmium-treated rats (1.2 mg Cd2+/kg) of various age groups (7-, 14-, 21- and 90-days-old) were determined. A significantly high concentration of native metallothionein was noticed in immature rats (7- and 14-days-old). Cadmium administration induced metallothionein only in 21- and 90-day-old rats, while the basal level of native metallothionein of immature rats was not altered. Activity of certain mixed-function oxidases (MFO) such as aryl hydrocarbon hydroxylase, aminopyrine-N-demethylase, and benzphetamine-N-demethylase was inhibited significantly only in 21- and 90-day-old rats. Microsomal cadmium accumulation was significantly higher in adult as compared to immature rats. Results suggest a protective role of metallothionein against cadmium-induced inhibition of mixed-function oxidases in immature rats.

Item Type:Article
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ID Code:29401
Deposited On:17 Dec 2010 08:07
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