Long-term occupational exposure to DDT

Siddiqui, M. K. J. ; Saxena, M. C. ; Mishra, U. K. ; Krishna Murti, C. R. ; Nag, D. (1981) Long-term occupational exposure to DDT International Archives of Occupational and Environmental Health, 48 (3). pp. 301-308. ISSN 0340-0131

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Related URL: http://dx.doi.org/10.1007/BF00405618


Blood serum of twenty workers occupationally exposed to DDT for an average duration of 14 years was analysed for organochlorine pesticides by gas-liquid chromatography with an electron capture detector. Significant levels of BHC, p,p'-DDT, p,p'-DDD and p,p-DDE were detected. A higher incidence of total DDT equivalent, about 10 times, was observed in DDT exposed workers when compared with a comparable sample of unexposed persons from the general population. Levels of DDT in serum of occupationally exposed workers were more than the permitted level of 200 ppb. The daily intake was computed to be about 10 mg/man/day as against 0.25 mg-the acceptable daily intale. Abnormal nerve conduction was encountered in a few cases of DDT sprayers. No significant correlation was observed between the total DDT equivalent in serum and duration of occupational exposure in workers. Levels of BHC in controls was 2.3 times the level in exposed workers, possibly due to induction of hepatic drug metabolising enzymes by high levels of DDT in the latter group. Findings are discussed in the light of existing knowledge of the bio-chemical effects evoked due to residual intoxication of DDT during occupational exposure.

Item Type:Article
Source:Copyright of this article belongs to Springer-Verlag.
Keywords:DDT; BHC; Nerve Conduction; Hepatic Microsomal Drug Metabolising Enzymes; Accepted Daily Intake
ID Code:29368
Deposited On:17 Dec 2010 08:10
Last Modified:17 May 2016 12:13

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