Enantioselective total synthesis of the polyketide natural product (-)-EI-1941-2: a novel interleukin-1β converting enzyme (ICE) inhibitor

Mehta, Goverdhan ; Roy, Subhrangsu (2005) Enantioselective total synthesis of the polyketide natural product (-)-EI-1941-2: a novel interleukin-1β converting enzyme (ICE) inhibitor Tetrahedron Letters, 46 (46). pp. 7927-7930. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2005.09.086

Abstract

An enantioselective total synthesis of the novel bioactive epoxyquinone natural product (-)-EI-1941-2, exhibiting promising ICE inhibiting activity, has been accomplished from a readily available chiron derived from the Diels-Alder adduct of cyclopentadiene and p-benzoquinone.

Item Type:Article
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ID Code:29349
Deposited On:17 Dec 2010 08:11
Last Modified:17 Dec 2010 08:11

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