A sequential RCM/fragmentation protocol towards chiral, stereodefined medium ring sesquiterpenoids. A carvone route to E- and Z-germacrenes

Mehta, Goverdhan ; Senthil Kumaran, R. (2005) A sequential RCM/fragmentation protocol towards chiral, stereodefined medium ring sesquiterpenoids. A carvone route to E- and Z-germacrenes Tetrahedron Letters, 46 (51). pp. 8831-8835. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2005.10.093

Abstract

A short, flexible and enantioselective approach towards 10-membered germacratrienones, from the commercially available monoterpene chiron (-)-carvone, involving RCM and Grob-type fragmentation as the pivotal steps is delineated.

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